The ultimate goal of our research is to understand the fundamental principles that control mechanical properties and behavior of materials in both engineering and biology by virtue of theoretical analyses, computational modelings, and experimental investigations. Our current research mainly focuses on mechanics of 2D nanomaterials and nanostructures; mechanical principles of cortical foldingmechanics of hierarchical structures in biological materials such as bone, shell and nacre; bio-inorganic interfaces; mechanics of cell and nanoparticle interactionsinstability of soft matters etc.